During the last two decades, the R&D ecosystem has been transformed by a shift to more patient-centric approaches to biomedical R&D. But as the scope and scale of patient engagement expand, efforts to align regulatory requirements and guidance must keep pace to streamline and maximize efforts at including patients in R&D endeavors. In a new era, when patient engagement is increasingly becoming standard practice, 1) What approaches should regulators, individual patients, patient organizations, and industry sponsors use to keep pace with trends in patient engagement in the medtech, digital health, and AI spaces? 2) How do R&D stakeholders measure the value and ROI in patient engagement? 3) How is patient engagement impacting reimbursement, coverage, and value? 4) How is patient-experience data being better leveraged as a research and decision-support resource? Experts on this panel will discuss the current state of these trends and what actions can be taken now (in light of these trends) to optimize patient engagement in the future.