We are at a pivotal time when efforts to advance diversity, equity, and inclusion are more important than ever to improve human health. A historical lack of equity in health care, coupled with recent actions such as the repeal of affirmative action, will increase broad systemic issues in biomedical research and clinical care. Evidence shows that the incorporation of diverse perspectives across the science and health ecosystem leads to innovative discoveries, improved treatments, and better health outcomes for all. Philanthropy can play a unique role in reimagining and rebuilding the scientific-health infrastructure with equity at the core. Several nonprofit organizations including private foundations, academic institutions and government entities have taken bold steps in recent years to do the hard work of reimagining and rebuilding these systems, through a variety of strategies, mechanisms, and partnerships to move the needle on building a diverse and equitable health ecosystem.